4-Piperidinemethanol → HCID 46932807, compound

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Reaction Steps

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (150 mg, 0.43 mmol) and piperidin-4-ylmethanol (59 mg, 0.51 mmol). The title compound was obtained as a solid (70 mg, 36% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, m), 7.89 (1H, s), 4.50 (1H, m), 4.25 (2H, m), 3.24 (2H, m), 1.68 (3H, m), 1.09 (2H, m). MS m/z: 448.34, 450.34 [M+H]+.

Provenance & Evidence