3-Hydroxypiperidine → HCID 46931305, compound

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Reaction Steps

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (150 mg, 0.43 mmol) and 3-hydroxyl piperidine (52 mg, 0.52 mmol). The title compound was obtained as a solid (22 mg, 12% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.97 (2H, m), 7.99 (1H, m), 4.96 (1H, m), 3.61 (3H, m), 1.72 (2H, m), 1.49 (2H, m). MS m/z: 434.08, 436.03 [M+H]+.

Provenance & Evidence