4-(Aminomethyl)-1-methylpiperidin-4-ol → HCID 67494845, compound

HRID 1192112Notes

Reaction equation

HRID 1192112 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[NH2:21][CH2:22][C:23]1([OH:30])[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:21][CH2:22][C:23]2([OH:30])[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 64842624-(Aminomethyl)-1-methylpiperidin-4-olHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 67494845HCID 67494845, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 4-(aminomethyl)-1-methylpiperidin-4-ol (14.4 mg, 0.1 mmol). The title compound was obtained as a solid (15.2 mg, 32% yield). MS m/z: 476.87, 478.86 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d9930f27abb44a74bd10f2fdb4127fad
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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