HCID 44141703, compound → HCID 60207331, compound

HRID 1192114Notes

Reaction equation

HRID 1192114 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH2:21]([N:23]1[CH2:27][C@H:26]([O:28][CH3:29])[C@@H:25]([NH2:30])[CH2:24]1)[CH3:22]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][C@@H:25]2[C@@H:26]([O:28][CH3:29])[CH2:27][N:23]([CH2:21][CH3:22])[CH2:24]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 44141703HCID 44141703, compoundHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207331HCID 60207331, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and (3S,4S)-1-ethyl-4-methoxypyrrolidin-3-amine (14.4 mg, 0.1 mmol). The title compound was obtained as a solid (7.9 mg, 17% yield). MS m/z: 476.86, 478.86 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-7bd5a2137df042a6ae6eddb430d8828e
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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