5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carbonyl chloride → 5-((3,5-dichloropyridin-4-yl)thio)-N-(4-(methylsulfonyl)benzyl)-4-nitrothiophene-2-carboxamide

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Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (100 mg, 0.27 mmol) and 4-methylsulfonyl-benzylamine hydrogen chloric acid salt (59 mg, 0.32 mmol). The title compound was obtained as a yellow solid (54 mg, 39% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.51 (1H, m), 8.99 (2H, s), 8.48 (1H, s), 7.89 (2H, dd), 7.55 (2H, dd), 4.51 (2H, m), 3.18 (3H, s). MS m/z: 515.97, 517.99 [M+H]+.

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