1-(3-Aminopropyl)-2-pyrrolidinone → 5-((3,5-dichloropyridin-4-yl)thio)-4-nitro-N-(3-(2-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxamide

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Reaction Steps

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (150 mg, 0.41 mmol) and 1-(3-amino-propyl)-2-pyrrolidinone (69 mg, 0.49 mmol). The title compound was obtained as a yellow solid (130 mg, 66% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, s), 8.32(1H, m), 8.40 (1H, s), 3.33 (1H, m), 3.20 (4H, m), 2.21 (2H, m), 1.90 (2H, m), 1.66 (2H, m). MS m/z: 475.03, 477.05 [M+H]+.

Provenance & Evidence