p-Bromophenethylamine → N-(4-bromophenethyl)-5-((3,5-dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxamide

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Reaction Steps

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (100 mg, 0.27 mmol) and 4-bromophenethylamine (65 mg, 0.32 mmol). The title compound was obtained as a solid (30 mg, 21% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, s), 8.88 (1H, m), 8.38 (1H, m), 7.47(2H, dd), 7.18 (2H, dd), 3.43 (2H, m), 2.78 (2H, m). MS m/z: 529.92, 531.95, 533.95 [M+H]+.

Provenance & Evidence