4-Chlorobenzylamine → N-(4-chlorobenzyl)-5-((3,5-dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxamide

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Reaction Steps

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (100 mg, 0.27 mmol) and 4-chlorobenzylamine (45 mg, 0.32 mmol). The title compound was obtained as a yellow solid (18 mg, 14% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.40 (1H, m), 8.99 (2H, s), 8.46 (1H, s), 7.43 (2H, dd), 7.31 (2H, dd), 4.39 (2H, m). MS m/z: 471.97, 473.95 [M+H]+.

Provenance & Evidence