2-(Pyridin-3-yl)ethan-1-amine → HCID 60207344, compound

HRID 1192129Notes

Reaction equation

HRID 1192129 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[NH2:21][CH2:22][CH2:23][C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:21][CH2:22][CH2:23][C:24]2[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 8540512-(Pyridin-3-yl)ethan-1-amineHCID 60207337HCID 60207337, compound

Product 1

HCID 60207344HCID 60207344, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (100 mg, 0.27 mmol) and 3-(2-aminoethyl)pyridine (39 mg, 0.32 mmol). The title compound was obtained as a solid (75 mg, 49% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, s), 8.91 (1H, m), 8.40 (2H, m), 8.38 (1H, s), 7.62 (1H, m), 7.30 (1H, m), 3.48 (2H, m), 2.81 (2H, m). MS m/z: 455.01, 457.00 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cce49607c24f4cf3a8dea35d3ccb9723
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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