2-(2-Fluorophenyl)ethylamine → HCID 67494952, compound

HRID 1192132Notes

Reaction equation

HRID 1192132 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]1[CH:30]=[CH:29][CH:28]=[CH:27][C:23]=1[CH2:24][CH2:25][NH2:26]>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:26][CH2:25][CH2:24][C:23]2[CH:27]=[CH:28][CH:29]=[CH:30][C:22]=2[F:21])=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 6433572-(2-Fluorophenyl)ethylamineHCID 60207337HCID 60207337, compound

Product 1

HCID 67494952HCID 67494952, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (150 mg, 0.41 mmol) and 2-fluoro-phenethylamine (67.9 mg, 0.49 mmol). The title compound was obtained as a solid (35 mg, 18% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, m), 8.97 (1H, m), 8.37 (1H, s), 7.27 (2H, m), 7.16 (2H, m), 3.44 (2H, m), 2.82 (2H, m). MS m/z: 470.00, 472.01 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-0ac8e7f91bb1437a9546de4c16550b5f
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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