4-(Trifluoromethoxy)benzylamine → HCID 60207350, compound

HRID 1192133Notes

Reaction equation

HRID 1192133 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]([F:33])([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][NH2:29])=[CH:26][CH:25]=1>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:29][CH2:28][C:27]2[CH:30]=[CH:31][C:24]([O:23][C:22]([F:21])([F:32])[F:33])=[CH:25][CH:26]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 5718464-(Trifluoromethoxy)benzylamineHCID 60207337HCID 60207337, compound

Product 1

HCID 60207350HCID 60207350, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (150 mg, 0.41 mmol) and 4-(trifluoromethoxy)-benzylamine (93 mg, 0.49 mmol). The title compound was obtained as a solid (50 mg, 30% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.42 (1H, m), 8.98 (2H, s), 8.47 (1H, s), 7.42 (2H, dd), 7.33 (2H, dd), 4.43 (2H, m). MS m/z: 521.98, 523.99 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-f2c13739643d4eee98fd906f7f8d9769
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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