3-(Pyridin-2-yl)propan-1-amine → HCID 60207351, compound

HRID 1192134Notes

Reaction equation

HRID 1192134 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][CH2:28][CH2:29][NH2:30]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][CH2:29][CH2:28][CH2:27][C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][N:21]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 31596143-(Pyridin-2-yl)propan-1-amineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207351HCID 60207351, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 3-(2-pyridyl)propan-1-amine (20.0 mg, 0.12 mmol). The title compound was obtained as a solid (14.5 mg, 26% yield). MS m/z: 469.01, 471.01 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dedae21f68fa4108a309c519fbec28f4
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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