3-Methoxypropylamine → HCID 60207355, compound

HRID 1192138Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][O:22][CH2:23][CH2:24][CH2:25][NH2:26]>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:26][CH2:25][CH2:24][CH2:23][O:22][CH3:21])=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

Reactant 2

HCID 16723-Methoxypropylamine

HCID 60207337HCID 60207337, compound

Product 1

HCID 60207355HCID 60207355, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (150 mg, 0.41 mmol) and 3-methoxypropylamine (44 mg, 0.49 mmol). The title compound was obtained as a solid (80 mg, 46% yield). 1H NMR (400MHz, d6-DMSO) δ: 8.99 (2H, s), 8.84 (1H, m), 8.42 (1H, s), 3.34 (1H, m), 3.33 (1H, m), 3.23 (5H, m), 1.69 (2H, m). MS m/z: 422.03, 424.03 [M+H]+.

Workup

customPrepared

Sources & evidence

ORD record: ord-be89365729c04cfab9567ca7d9000da2
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08680139B2

Reaction notes

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