p-Fluorophenethylamine → HCID 60207356, compound

HRID 1192139Notes

Reaction equation

HRID 1192139 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]1[CH:30]=[CH:29][C:25]([CH2:26][CH2:27][NH2:28])=[CH:24][CH:23]=1>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:28][CH2:27][CH2:26][C:25]2[CH:29]=[CH:30][C:22]([F:21])=[CH:23][CH:24]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 4653p-FluorophenethylamineHCID 602073375-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carbonyl chloride

Product 1

HCID 60207356HCID 60207356, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (150 mg, 0.41 mmol) and 4-fluorophenethylamine (68 mg, 0.49 mmol). The title compound was obtained as a solid (50 mg, 26% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.99 (2H, s), 8.93 (1H, m), 8.39 (1H, s), 37.23 (2H, dd), 7.10 (2H, dd), 3.41 (2H, m), 2.77 (2H, m). MS m/z: 470.04, 472.03 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-9b848e13d9f343948e7e366e6ec587cb
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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