3-Fluorobenzylamine → HCID 60207364, compound

HRID 1192145Notes

Reaction equation

HRID 1192145 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]1[CH:23]=[C:24]([CH:27]=[CH:28][CH:29]=1)[CH2:25][NH2:26]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:26][CH2:25][C:24]2[CH:27]=[CH:28][CH:29]=[C:22]([F:21])[CH:23]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 668533-FluorobenzylamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207364HCID 60207364, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 3-fluorobenzylamine (14.0 mg, 0.12 mmol). The title compound was obtained as a solid (22.5 mg, 49% yield). MS m/z: 457.96, 459.96 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-291af9ce52874344ae66841f7b99e07f
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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