Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1192154Generated: October 30, 2026

4-Fluoro-2-(trifluoromethyl)aniline → HCID 60207373, compound

https://huagongshe.com/reaction/1192154

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluoro-2-(trifluoromethyl)anilineHCID 67853—
Reactant5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carbonyl chlorideHCID 60207337—
ProductHCID 60207373HCID 60207373—

Reaction Steps

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and 4-fluoro-2-trifluoromethyl-aniline (69 mg, 0.39 mmol). The title compound was obtained as a solid (60 mg, 36% yield). 1H NMR (400 MHz, d6-DMSO) δ: 10.55 (1H, s), 8.99 (2H, m), 8.64 (1H, s), 7.73 (1H, m), 7.64 (1H, m), 7.58 (1H, m). MS m/z: 510.02, 512.00 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08680139B2
Source datasetuspto-grants-2014_03
ORD IDord-6fc3a9cda56741c783adaaf7788e197a
Source noteuspto-grants-2014_03