4-Fluoro-3-(trifluoromethyl)aniline → HCID 86664725, compound

HRID 1192155Notes

Reaction equation

HRID 1192155 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][C:23]=1[C:29]([F:32])([F:31])[F:30]>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:26][C:25]2[CH:27]=[CH:28][C:22]([F:21])=[C:23]([C:29]([F:32])([F:30])[F:31])[CH:24]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 753774-Fluoro-3-(trifluoromethyl)anilineHCID 60207337HCID 60207337, compound

Product 1

HCID 86664725HCID 86664725, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and 4-fluoro-3-trifluoromethyl-aniline (69 mg, 0.39 mmol). The title compound was obtained as a solid (95 mg, 57% yield). 1H NMR (400 MHz, d6-DMSO) δ: 10.82 (1H, s), 9.01 (2H, s), 8.68 (1H, s), 8.09 (1H, m), 7.97 (1H, m), 7.54 (1H, m). MS m/z: 510.03, 512.02 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-ebddc6a8c29347bbabf2c8f43b7c8820
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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