3-(Trifluoromethyl)benzylamine → HCID 60207379, compound

HRID 1192161Notes

Reaction equation

HRID 1192161 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]([F:32])([F:31])[C:23]1[CH:24]=[C:25]([CH:28]=[CH:29][CH:30]=1)[CH2:26][NH2:27]>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:27][CH2:26][C:25]2[CH:28]=[CH:29][CH:30]=[C:23]([C:22]([F:21])([F:31])[F:32])[CH:24]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 759623-(Trifluoromethyl)benzylamineHCID 602073375-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carbonyl chloride

Product 1

HCID 60207379HCID 60207379, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and 3-(trifluoromethyl)benzylamine (47 mg, 0.39 mmol). The title compound was obtained as a solid (87 mg, 52% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.48 (1H, m), 8.99 (2H, s), 8.47 (1H, s), 7.64 (2H, m), 7.57 (1H, m), 4.56 (2H, m). MS m/z: 506.07, 508.07 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-91734ddb692047269e8e05cf2899f955
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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