1-(3-ethoxyphenyl)methanamine → HCID 60207380, compound

HRID 1192162Notes

Reaction equation

HRID 1192162 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14](Cl)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH2:21]([O:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][CH:31]=1)[CH2:27][NH2:28])[CH3:22]>>[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:28][CH2:27][C:26]2[CH:29]=[CH:30][CH:31]=[C:24]([O:23][CH2:21][CH3:22])[CH:25]=2)=[O:15])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 70162241-(3-ethoxyphenyl)methanamineHCID 60207337HCID 60207337, compound

Product 1

HCID 60207380HCID 60207380, compound

Procedure

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and 3-ethoxybenzylamine (58.3 mg, 0.39 mmol). The title compound was obtained as a solid (71 mg, 45% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.36 (1H, m), 8.99 (2H, s), 8.48 (1H, s), 7.22 (1H, m), 6.81 (3H, m), 4.36 (2H, m), 3.99 (2H, q), 1.30 (3H, t). MS m/z: 482.13, 484.10 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-68d731fdd912434589d0c41fca1c0a76
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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