2,5-Difluoroaniline → HCID 60207387, compound

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Reaction Steps

Prepared according to the procedure described for example 50 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carbonyl chloride (120 mg, 0.33 mmol) and 2,5-difluoroaniline (50 mg, 0.39 mmol). The title compound was obtained as a solid (45 mg, 44% yield). 1H NMR (400 MHz, d6-DMSO) δ: 10.62 (1H, m), 9.00 (2H, s), 8.75 (1H, s), 7.50 (1H, m), 7.48 (1H, m), 7.40 (1H, m). MS m/z: 460.05, 462.04 [M+H]+.

Provenance & Evidence