5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid → HCID 178522161, compound

HRID 1192176Notes

Reaction equation

HRID 1192176 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[F:21][C:22]([F:30])([F:29])[C:23]1[CH:27]=[C:26]([NH2:28])[NH:25][N:24]=1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:28][C:26]2[NH:25][N:24]=[C:23]([C:22]([F:30])([F:29])[F:21])[CH:27]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acidHCID 178507669HCID 178507669, compound

Product 1

HCID 178522161HCID 178522161, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 3-(trifluoromethyl)-1H-pyrazol-5-amine (18.0 mg, 0.12 mmol). The title compound was obtained as a solid (13.0 mg, 27% yield). MS m/z: 483.93, 485.93 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-65858c6fa0fd422987b8b3c16b44ebb9
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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