2-Aminothiazole → HCID 60207399, compound

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Reaction Steps

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (150 mg, 0.43 mmol) and aminothiazole (51.2 mg, 0.51 mmol). The title compound was obtained as a brown solid (77.0 mg, 42% yield). 1H NMR (400 MHz, d6-DMSO) δ: 13.12 (1H, br), 9.02 (2H, s), 7.73 (1H, m), 7.24 (1H, m). MS m/z: 431.20, 433.13 [M+H]+.

Provenance & Evidence