5-Aminoisoquinoline → HCID 67494866, compound

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Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (150 mg, 0.43 mmol) and 5-aminoisoquinoline (73.7 mg, 0.51 mmol). The title compound was obtained as a yellow solid (23.0 mg, 12% yield). 1H NMR (400 MHz, d6-DMSO) δ: 10.85 (1H, br), 9.36 (1H, s), 9.00 (2H, s), 8.83 (1H, m), 8.54 (1H, m), 8.08 (1H, m), 7.84 (2H, m), 7.71 (1H, m). MS m/z: 475.17, 477.12 [M+H]+.

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