HuagongsheHuagongshe Chemistry Print Report · For research reference only
8-Methyl-8-azabicyclo[3.2.1]octan-3-amine → HCID 60207408, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 8-Methyl-8-azabicyclo[3.2.1]octan-3-amine | HCID 408394 | — |
| Reactant | 5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid | HCID 60207317 | — |
| Product | HCID 60207408 | HCID 60207408 | — |
Reaction Steps
Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (150 mg, 0.43 mmol) and 8-methyl-8-azabicyclo[3.2.1]octan-3-amine (71.0 mg, 0.52 mmol). The title compound was obtained as a solid (40 mg, 20% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.97 (2H, m), 8.52 (1H, s), 8.44 (1H, s), 3.85 (1H, m), 3.79 (2H, m), 2.64 (3H, m), 2.25 (2H, m), 2.22 (4H, m), 2.16 (2H, m). MS m/z: 475.35, 477.33 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680139B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-896dd288d30040efaf6a87626c79fd74 |
| Source note | uspto-grants-2014_03 |