4-Piperidineethanamine,1-ethyl-(9CI) → HCID 60207409, compound

HRID 1192194Notes

Reaction equation

HRID 1192194 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH2:21]([N:23]1[CH2:28][CH2:27][CH:26]([CH2:29][CH2:30][NH2:31])[CH2:25][CH2:24]1)[CH3:22]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:31][CH2:30][CH2:29][CH:26]2[CH2:25][CH2:24][N:23]([CH2:21][CH3:22])[CH2:28][CH2:27]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 216439024-Piperidineethanamine,1-ethyl-(9CI)HCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207409HCID 60207409, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 2-(1-ethylpiperidin-4-yl)ethanamine (15.6 mg, 0.12 mmol). The title compound was obtained as a solid (26.1 mg, 53% yield). MS m/z: 489.06, 491.06 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-602033de7c294d40a48d5e30f825806a
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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