4-Amino-1,2,2,6,6-pentamethylpiperidine → HCID 60207412, compound

HRID 1192197Notes

Reaction equation

HRID 1192197 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][N:22]1[C:27]([CH3:29])([CH3:28])[CH2:26][CH:25]([NH2:30])[CH2:24][C:23]1([CH3:32])[CH3:31]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][CH:25]2[CH2:24][C:23]([CH3:31])([CH3:32])[N:22]([CH3:21])[C:27]([CH3:29])([CH3:28])[CH2:26]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 6937924-Amino-1,2,2,6,6-pentamethylpiperidineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207412HCID 60207412, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (35 mg, 0.1 mmol) and 1,2,2,6,6-pentamethylpiperidin-4-amine (20.4 mg, 0.12 mmol). The title compound was obtained as a solid (16.9 mg, 34% yield). MS m/z: 503.09, 505.08 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-cda6d4579faa4b5a9ac498354cf32842
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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