Hydrochloric Acid → HCID 60207421, compound

Participants

Reaction Steps

tert-butyl 3-(5-((3,5-dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxamido)pyrrolidine-1-carboxylate (3.0 g, 5.63 mmol) from the above was added to a solution of hydrogen chloride in ethanol (2.0 M, 20 mL) and ethanol (30 mL), and the resulting mixture was stirred at ambient temperature for 4 hours. After this time, the mixture was concentrated, washed with dry ether and dried in vacuo overnight to afford the title product as a white solid (2.2 g, 91% yield). 1H NMR (400 MHz, d6-DMSO) δ: 8.98 (2H, m), 8.86 (1H, d), 8.78 (1H, m), 8.50 (1H, s), 4.20 (1H, m), 2.94 (2H, m), 2.79 (1H, m), 2.67 (1H, m), 1.93 (1H, m), 1.67 (1H, m). MS m/z: 419.20, 421.20 [M+H]+.

Provenance & Evidence