Glycine ethyl ester → HCID 60207435, compound

HRID 1192214Notes

Reaction equation

HRID 1192214 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[NH2:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:21][CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 12176Glycine ethyl esterHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207435HCID 60207435, compound

Procedure

Prepared according to the procedure described for example 70 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (1.5 g, 4.27 mmol) and ethyl 2-aminoacetate (696 mg, 5.12 mmol). The title compound was obtained as a solid (1.1 g, 59% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.36 (1H, t), 8.98 (2H, s), 8.47 (1H, s), 4.11 (2H, q), 3.97 (2H, s), 1.19 (3H, t). MS m/z: 434.08, 436.06 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-e7e7a21c949c499898e6401090355578
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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