4-Fluoropiperidine → HCID 60207442, compound

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Reaction Steps

Prepared according to the procedure described for example 70 from 2-(5-((3,5-dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxamido)acetic acid (200 mg, 0.49 mmol) from example 210 and 4-fluoro-piperidine (60.0 mg, 0.59 mmol). The title compound was obtained as a solid (50.0 mg, 20% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.07 (1H, m), 8.98 (2H, m), 8.51 (1H, s), 4.93 (1H, m), 4.10 (2H, m), 3.54 (2H, m), 3.44 (2H, m), 1.92 (1H, m), 1.74 (2H, m), 1.61 (1H, m). MS m/z: 491.39, 493.37 [M+H]+.

Provenance & Evidence