4-Amino-1-methylpiperidine → HCID 60207447, compound

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Reaction Steps

Prepared according to the procedure described for example 70 from 2-(5-((3,5-dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxamido)acetic acid (120.0 mg, 0.29 mmol) from example 210 and N-methyl-4-amino-piperidine (40.2 mg, 0.35 mmol). The title compound was obtained as a solid (30.0 mg, 21% yield). 1H NMR (400 MHz, d6-DMSO) δ: 9.14 (1H, m), 8.99 (2H, m), 8.48 (1H, s), 7.90 (1H, m), 3.77 (2H, m), 3.48 (1H, m), 2.69 (2H, m), 2.15 (3H, s), 1.92 (2H, m), 1.67 (2H, m), 1.44 (2H, m). MS m/z: 502.15, 504.12 [M+H]+.

Provenance & Evidence