5-Methoxy-3-pyridinemethanamine → HCID 60207461, compound

HRID 1192243Notes

Reaction equation

HRID 1192243 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH3:21][O:22][C:23]1[CH:24]=[C:25]([CH2:29][NH2:30])[CH:26]=[N:27][CH:28]=1>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[S:8][C:9]1[S:13][C:12]([C:14]([NH:30][CH2:29][C:25]2[CH:26]=[N:27][CH:28]=[C:23]([O:22][CH3:21])[CH:24]=2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 595697865-Methoxy-3-pyridinemethanamineHCID 602073175-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophene-2-carboxylic acid

Product 1

HCID 60207461HCID 60207461, compound

Procedure

Prepared according to the procedure described for example 44 from 5-[(3,5-dichloro-4-pyridyl)sulfanyl]-4-nitro-thiophene-2-carboxylic acid (28 mg, 0.08 mmol) and (5-methoxypyridin-3-yl)methanamine (13.8 mg, 0.1 mmol). The title compound was obtained as a solid (20 mg, 43% yield). MS m/z: 470.98, 472.98 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3e266d276f9648e9a3f35bce6519e595
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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