Methyl 5-chloro-4-nitrothiophene-2-carboxylate → 3,5-Dichloro-4-((5-(methoxycarbonyl)-3-nitrothiophen-2-yl)thio)pyridine 1-oxide

Participants

Reaction Steps

Prepared according to the procedure described for example 18 from methyl 5-chloro-4-nitrothiophene-2-carboxylate (500 mg, 2.26 mmol) and 3,5-dichloro-4-mercaptopyridine 1-oxide (441 mg, 2.26 mmol) from step A of example 18. The titled product was obtained as a solid (250 mg, 29% yield). The crude was used as such for the next step transformation.

Provenance & Evidence