4-Amino-1-methylpiperidine → HCID 67494831, compound

HRID 1192256Notes

Reaction equation

HRID 1192256 reaction equation
[C:1]([C:3]1[C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:5]([C:17]([OH:19])=O)[S:6][C:7]=1[S:8][C:9]1[C:14]([Cl:15])=[CH:13][N:12]=[CH:11][C:10]=1[Cl:16])#[N:2].[CH3:26][N:27]1[CH2:32][CH2:31][CH:30]([NH2:33])[CH2:29][CH2:28]1>>[C:1]([C:3]1[C:4]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[C:5]([C:17]([NH:33][CH:30]2[CH2:31][CH2:32][N:27]([CH3:26])[CH2:28][CH2:29]2)=[O:19])[S:6][C:7]=1[S:8][C:9]1[C:14]([Cl:15])=[CH:13][N:12]=[CH:11][C:10]=1[Cl:16])#[N:2]

Participants

3

Reactant 2

HCID 27375314-Amino-1-methylpiperidineHCID 60207475HCID 60207475, compound

Product 1

HCID 67494831HCID 67494831, compound

Procedure

Prepared according to the procedure described for step A of example 44 from 4-cyano-5-((3,5-dichloropyridin-4-yl)thio)-3-phenylthiophene-2-carboxylic acid from above and 1-methylpiperidin-4-amine (0.11 g, 1.0 mmol). The title product was obtained as a white solid (29.5 mg, 6.0% yield). MS m/z: 503.04, 505.04 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-56c3ace97cdb4de0b2b858e71b55590d
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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