1-(Propan-2-yl)piperidin-4-amine → HCID 60207491, compound

HRID 1192268Notes

Reaction equation

HRID 1192268 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:20])[C:7]=1[O:8][C:9]1[S:13][C:12]([C:14]([OH:16])=O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18].[CH:21]([N:24]1[CH2:29][CH2:28][CH:27]([NH2:30])[CH2:26][CH2:25]1)([CH3:23])[CH3:22]>>[Cl:20][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[O:8][C:9]1[S:13][C:12]([C:14]([NH:30][CH:27]2[CH2:28][CH2:29][N:24]([CH:21]([CH3:23])[CH3:22])[CH2:25][CH2:26]2)=[O:16])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18]

Participants

3

Reactant 2

HCID 31633331-(Propan-2-yl)piperidin-4-amineHCID 60207489HCID 60207489, compound

Product 1

HCID 60207491HCID 60207491, compound

Procedure

Prepared according to the procedure described for example 44 from 5-((3,5-dichloropyridin-4-yl)oxy)-4-nitrothiophene-2-carboxylic acid (10 mg, 0.03 mmol) from above and 1-isopropylpiperidin-4-amine (17.4 mg, 0.1 mmol). The title compound was obtained as a solid (1.0 mg, 7% yield). MS m/z: 459.01, 461.01 [M+H]+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-d99b8ab43e4a4506a85812bf9ed191f8
Source dataset
uspto-grants-2014_03
Patent number
US08680139B2

Reaction notes

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