1-(5-Chloro-4-nitrothiophen-2-yl)-3-(1-methylpiperidin-4-yl)urea → 1-(5-((3,5-Dichloropyridin-4-yl)thio)-4-nitrothiophen-2-yl)-3-(1-methylpiperidin-4-yl)urea

Participants

Reaction Steps

Prepared according to the procedure described for step A of example 18 from 1-(5-chloro-4-nitrothiophen-2-yl)-3-(1-methylpiperidin-4-yl)urea (100 mg, 0.31 mmol) and 3,5-dichloropyridine-4-thiol sodium salt (62 mg, 0.35 mmol). The title compound was obtained as a white solid (120 mg, 85% yield). 1H NMR (400 MHz, d6-DMSO) δ: 10.01 (1H, m), 8.92 (2H, m), 6.91 (1H, m), 3.43 (2H, m), 2.87 (2H, m), 2.33 (3H, m), 1.91 (1H, m), 1.74 (2H, m), 1.46 (2H, m). MS m/z: 459.94, 461.94 [M+H]+.

Provenance & Evidence