HCID 21477601, compound → HCID 67539064, compound

HRID 1192324Notes

Reaction equation

HRID 1192324 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([NH2:20])=[CH:18][N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:21]C1C=C(Cl)N=C([N+]([O-])=O)N=1>>[ClH:21].[ClH:21].[N:11]1([C:14]2[C:19]([NH2:20])=[CH:18][N:17]=[CH:16][N:15]=2)[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 21477601HCID 21477601, compoundHCID 53951280HCID 53951280, compound

Product 1

HCID 67539064HCID 67539064, compound

Procedure

4-Piperazin-1-yl-pyrimidin-5-ylamine dihydrochloride was prepared by the procedures described in Example 34, Step 3, substituting (2R)-{1-(4-chlorobenzyl)-2-[4-(1H-indazol-5-yl)-piperazin-1-yl]-2-oxo-ethyl}-carbamic acid tert-butyl ester with 4-(5-aminopyrimidin-4-yl)-piperazine-1-carboxylic acid tert-butyl ester (prepared from 4,6-dichloro-nitropyrimidine according to the procedures described in U.S. Pat. No. 5,563,142). LCMS (APCI+) m/z 180 [M+H]+; Rt=1.12 minutes.

Sources & evidence

ORD record
ord-fdca7afa8a21480ba877cfe0f7e9409e
Source dataset
uspto-grants-2014_03
Patent number
US08680114B2

Reaction notes

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