HCID 67539976, compound → HCID 67537632, compound

Participants

Reaction Steps

To a suspension of Pd/C (5% w/w, 800 mg, 0.38 mmol) in 100 mL 2-methoxyethanol (degassed with nitrogen prior to use) was added a solution of 4-(6-nitro-quinazolin-4-yl)-1-Boc-piperazine (4.0 g, 11.1 mmol) in 10 mL 2-methoxyethanol. A balloon of H2 was bubbled through the reaction mixture, and the reaction mixture was stirred at room temperature under an atmosphere of H2 for 13 hours. Celite was then added, and the reaction mixture was filtered through a pad of celite and rinsed with MeOH. The filtrate was concentrated, and the resulting oil was filtered through a short plug of silica gel with EtOAc. The resulting filtrate was concentrated to give 4-(6-amino-quinazolin-4-yl)-1-Boc-piperazine (3.47 g, 95%). LCMS (APCI+) m/z 330 [M+H]+. HPLC Rt 2.31 min.

Provenance & Evidence