HCID 86656159, compound → HCID 67258278, compound

Participants

Reaction Steps

To a mixture of 4-bromo-2-methyl-1,3-benzothiazole-5-carbaldehyde (1.70 g, 6.64 mmol) in tetrahydrofuran (30 mL) was added 1.40 M methylmagnesium bromide in tetrahydrofuran (9.48 mL) at 0° C. The reaction was stirred at room temperature for 30 minutes, quenched with water, and extracted with EtOAc. The combined organic layers were washed with brine, dried over magnesium sulfate, and then concentrated to dryness under reduced pressure. The crude residue was used directly in next step (1.81 g, 100%). LCMS calculated for C10H11BrNOS(M+H)+: m/z=272.0; found: 271.9.

Provenance & Evidence