反应详情

A mixture of 6-bromo-9H-purine (0.0174 g, 0.0876 mmol), 1-{5-chloro-8-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]quinolin-7-yl]ethanamine (0.014 g, 0.044 mmol), and N,N-diisopropylethylamine (0.01525 mL, 0.0876 mmol) in ethanol (0.1 mL) was heated at reflux under nitrogen overnight. The mixture was evaporated and the resultant residue was purified on RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/minute) to give the product as a mixture of diastereoisomers (bis-TFA salts). LCMS calculated for C22H25ClN7O(M+H)+: m/z=438.2; found: 438.2.

1. temperaturewas heated
2. temperatureat reflux under nitrogen overnight
3. customThe mixture was evaporated
4. customthe resultant residue was purified on RP-HPLC (XBridge C18 column
5. washeluting with a gradient of acetonitrile/water containing 0.05% TFA, at flow rate of 30 mL/minute)
6. customto give the product