Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Trimethylphosphine | HCID 68983 | — |
| Reactant | HCID 58368577 | HCID 58368577 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 58368472 | HCID 58368472 | — |
Reaction Steps
A solution of peak 1 of 7-(1-azidoethyl)-5-chloro-8-(3-fluorophenyl)cinnoline (0.57 g, 1.7 mmol), from step A, in tetrahydrofuran (9.3 mL) and water (1.8 mL) was treated with 1 M of trimethylphosphine in tetrahydrofuran (2.1 mL, 2.1 mmol) and stirred at 20° C. for 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08680108B2 |
|---|
| Source dataset | uspto-grants-2014_03 |
|---|
| ORD ID | ord-60cc3c09a0dc4cb7afec51f0c0a9fdcb |
|---|
| Source note | uspto-grants-2014_03 |
|---|
