Potassium Carbonate → HCID 178436984, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-{6-[(1E)-3,3-diethyltriaz-1-en-1-yl]-3′,4-difluoro-5-[(trimethylsilyl)ethynyl]biphenyl-2-yl}ethanone (2.0 g, 4.6 mmol) in tetrahydrofuran (39 mL) and methanol (7.7 mL) was treated with powdered potassium carbonate (3.2 g, 23 mmol) and stirred at 0° C. for 2 hours. The reaction mixture was filtered and the filtrate was treated with a few drops of water. The filtrate was concentrated to an oil that was diluted with ethyl acetate (150 mL), washed with water (50 mL) and brine (25 mL), dried with sodium sulfate, filtered, and concentrated to give the desired product (1.6 g, 99%) that was used without further purification. LCMS for C20H20F2N3O (M+H)+: m/z=356.2; Found: 355.9.

Provenance & Evidence