HCID 58368653, compound → HCID 58368424, compound

Participants

Reaction Steps

To a mixture of 8-(3-fluorophenyl)-N-methoxy-N-methyl-5-vinylquinoline-7-carboxamide (32 mg, 0.095 mmol) in tetrahydrofuran (0.2 mL) was added 1.4 M methylmagnesium bromide in tetrahydrofuran (0.20 mL, 0.29 mmol) at 0° C. The reaction was stirred at room temperature for 1 hour, quenched with sat. ammonium chloride. The resulting mixture was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over magnesium sulfate and concentrated to dryness. The crude product was used directly in the next step (26 mg, 94%). LCMS calculated for C19H15FNO (M+H)+: m/z=292.1; Found: 292.1.

Provenance & Evidence