Tetrahydrofuran → HCID 58368609, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-{5-chloro-8-[4-(3-fluorobenzoyl)piperazin-1-yl]quinolin-7-yl}ethanone (0.045 g, 0.11 mmol) and ammonium acetate (0.0842 g, 1.09 mmol) in methanol (0.4 mL) and acetonitrile (0.4 mL) was heated at 65° C. in a sealed tube for 1 hour. After cooling to room temperature, to the resulting mixture was added 1.0 M sodium cyanoborohydride in tetrahydrofuran (0.27 mL, 0.27 mmol). The reaction was heated at 65° C. overnight. The mixture was cooled to room temperature, quenched with sat. NaHCO3 solution, extracted with dichloromethane, dried over MgSO4 and concentrated to give the desired product. LCMS calculated for C22H23ClFN4O (M+H)+: m/z=413.2; Found: 413.1.

Provenance & Evidence