Tetrahydrofuran → HCID 58368419, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-{5-chloro-8-[4-(pyrazin-2-ylcarbonyl)piperazin-1-yl]quinolin-7-yl}ethanone (0.028 g, 0.071 mmol) and ammonium acetate (0.0545 g, 0.707 mmol) in methanol (0.3 mL) and acetonitrile (0.3 mL) was heated at 65° C. in a sealed tube for 1 hour. After cooling to room temperature, to the resulting mixture was added 1.0 M sodium cyanoborohydride in tetrahydrofuran (0.17 mL, 0.17 mmol). The reaction was heated at 65° C. overnight. The mixture was cooled to room temperature, quenched with sat. NaHCO3 solution, extracted with dichloromethane, dried over MgSO4 and concentrated to give the desired product. LCMS calculated for C20H22ClN6O (M+H)+: m/z=397.2; Found: 397.1.

Provenance & Evidence