Tetrahydrofuran → HCID 58368530, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[5-chloro-8-(4-isonicotinoylpiperazin-1-yl)quinolin-7-yl]ethanone (0.030 g, 0.076 mmol) and ammonium acetate (0.0586 g, 0.760 mmol) in methanol (0.3 mL) and acetonitrile (0.3 mL) was heated at 65° C. in a sealed tube for 1 hour. After cooling to room temperature, to the resulting mixture was added 1.0 M sodium cyanoborohydride in tetrahydrofuran (0.19 mL, 0.19 mmol). The reaction was heated at 65° C. overnight. The mixture was cooled to room temperature, quenched with sat. NaHCO3 solution, extracted with dichloromethane, dried over MgSO4 and concentrated to give the desired product. LCMS calculated for C21H23ClN5O (M+H)+: m/z=396.2; Found: 396.2.

Provenance & Evidence