Nitric Acid → HCID 58368656, compound

HRID 1192697Notes

Reaction equation

HRID 1192697 reaction equation
[Cl:1][C:2]1[C:3]([I:13])=[CH:4][C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8].[N+:14]([O-])([OH:16])=[O:15]>C(O)(=O)C>[Cl:1][C:2]1[C:3]([I:13])=[C:4]([N+:14]([O-:16])=[O:15])[C:5]([OH:12])=[C:6]([CH:11]=1)[C:7]([O:9][CH3:10])=[O:8]

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 58368557HCID 58368557, compound

Product 1

HCID 58368656HCID 58368656, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

To a mixture of methyl 5-chloro-2-hydroxy-4-iodobenzoate (5.1 g, 16 mmol) in acetic acid (50 mL) was added nitric acid (6.8 mL) at room temperature. The reaction was stirred at 60° C. for 90 min and then cooled and poured into ice water. The precipitate was collected by filtration, washed with water and air dried to give the desired product (5.15 g, 88%).

Workup

  1. temperaturecooled
  2. filtrationThe precipitate was collected by filtration
  3. washwashed with water and air
  4. customdried

Sources & evidence

ORD record
ord-a2a71687d32340b09e9b1416c817b85a
Source dataset
uspto-grants-2014_03
Patent number
US08680108B2

Reaction notes

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