Water → HCID 58368464, compound

Participants

Reaction Steps

A solution of (2R,3R)-2,3-dihydroxysuccinic acid-(1S)-1-[5-chloro-8-(3-fluorophenyl)cinnolin-7-yl]ethanamine (0.75:1) (43 g, 103 mmol) in methylene chloride (570 mL) was treated with 2.0 M sodium carbonate in water (400 mL, 800 mmol) was added. The reaction mixture was treated with additional methylene chloride (400 mL) to dissolve the solid that had formed a ball. The methylene chloride solution was separated and concentrated to give the desired product (29 g, 94%) as an off-white solid. This material was used directly in the next step without further purification.

Provenance & Evidence