Hydrochloric Acid → HCID 86653383, compound

Participants

Reaction Steps

To a solution of ethyl cis-eicosapentaenoate (5 g, 15.15 mmol) in methanol (100 mL) was added an aqueous solution of sodium hydroxide (6 g, 150 mmol, in 20 mL of water) at rt and stirred for 1.5 h. The reaction mixture was poured into ice cooled water and acidified with dil. HCl. The solution was extracted with dichloromethane (3×50 mL) and the combined layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the acid (4.4 g, 96%) as an oil; LCMS (ESI, negative ion mode): m/z 301 (M-H)−.

Provenance & Evidence