4-(Trifluoromethoxy)phenylboronic acid → HCID 57824456, compound

HRID 1192809Notes

Reaction equation

HRID 1192809 reaction equation
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([C:8]2[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=2)[N:3]=1.[F:16][C:17]([F:29])([F:28])[O:18][C:19]1[CH:24]=[CH:23][C:22](B(O)O)=[CH:21][CH:20]=1>[Pd]>[F:16][C:17]([F:28])([F:29])[O:18][C:19]1[CH:24]=[CH:23][C:22]([C:2]2[CH:7]=[CH:6][N:5]=[C:4]([C:8]3[CH:15]=[CH:14][C:11]([CH:12]=[O:13])=[CH:10][CH:9]=3)[N:3]=2)=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 57824452HCID 57824452, compound

Product 1

HCID 57824456HCID 57824456, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The compound was prepared by palladium-catalyzed arylation of the product of Step 1 with 4-trifluoromethoxyphenyl boronic acid: 1H NMR (400 MHz, CDCl3) δ 10.14 (s, 1H), 8.91 (d, J=4.2 Hz, 1H), 8.63 (d, J=8.5 Hz, 2H), 8.37 (d, J=8.4 Hz, 2H), 8.06 (d, J=8.8 Hz, 2H), 7.67 (d, J=5.4 Hz, 1H), 7.35 (d, J=8.7 Hz, 2H); EIMS m/z 344 (M+).

Sources & evidence

ORD record
ord-0f467bfe633c4b27aad51032359df1b2
Source dataset
uspto-grants-2014_03
Patent number
US08680269B2

Reaction notes

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