Methanol → HCID 178488037, compound

Participants

Reaction Steps

30% sodium methoxide in methanol (4.7 mL, 25.3 mmol) was added dropwise at room temperature to a solution of esomeprazole (8.5 g, 24.6 mmol; 2.2% sulfone) in methyl isobutyl ketone (60 mL). The resulting slurry was stirred overnight. The solid was collected by filtration, rinsed with methyl isobutyl ketone (2×10 mL) and dried under reduced pressure at 50° C. to yield esomeprazole sodium. Yield: 6.3 g (70%). Sulfone content: 0.33%.

Provenance & Evidence